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Abstract

FORMULATION AND EVALUATION OF MUCCOADHESIVE BUCCAL TABLETS OF TIZANIDINE HYDROCHLORIDE BY USING POLYMETHYLOLCARBAMIDE: A NOVEL MUCCOADHESIVE POLYMER

Hariprasanna R.C *1, 2, S.S.Bushetti 3

1Research Scholar, Acharya Nagarjuna University, Guntur. India.
2R.M.E.Sís College of Pharmacy, Old Jewargi Road, Gulbarga-Karnataka. India.
3H.K.E.Sís College of Pharmacy, Sedam Road, Gulbarga-Karnataka. India.

ABSTRACT

The buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and provides rapid absorption for drugs than oral route.Tizanidine is a non-selective, α-2 adrenergic agonist receptor. Because of poor bioavailability of Tizanidine by oral route, there is a need to increase its bioavailability by formulating it into buccal dosage forms. Hence, Tizanidine is a suitable drug for buccal dosage forms and may provide a better therapeutic profile than oral route. In the present investigation Tizanidine Hydrochloride Buccal tablets were prepared by using novel muccoadhesive polymer Polymethylolcarbamide (PMC) in comparison with the standard HPMC K15. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, swelling index, muccoadhesive strength, In- vitro drug release and In-Vivo muccoadhesive behavior of optimized formulation. All the formulations displayed zero order kinetics. Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The in vitro release parameter values displayed by the various formulations fabricated by HPMC shows, formulation TH I (40% polymer) was released more than 90% of drug within 3hrs, formulation TH II (40% polymer) was released more than 90% of drug at 4th hr, and in case of formulation TH III (50% polymer) was released more than 90% of drug at the end of 6th hr. In case of formulations fabricated by novel polymer PMC, formulation TP I (40% polymer) was controlled the drug release up to 6th by releasing 93.65%, formulation TP II was released 75.65% drug at the end of 6th hr whereas formulation TP III was released 70.16% at the end of 6th hr. from these results it was concluded that the novel PMC is more superior than existing polymers in order to control the drug release.

Keywords: Tizanidine Hydrochloride, Novel muccoadhesive polymer, PMC, HPMC K15.


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