Abstract

DEFICIENCY OF VITAMIN D IN PATIENTS SUFFERING FROM TUBERCULOSIS

Neelam Dubey* and Abha Goyal

ABSTRACT

Vitamin D deficiency was deliberated to be unusual in India till recently. Following with the observation of Vitamin D deficiency in patients with Tuberculosis, a controlled study was done to verify that. Vitamin D levels in patients with recently analyzed active Tuberculosis and matched healthy controls were compared. Hydroxy vitamin D3 level was estimated utilizing a sensitive RIA technique, Adequacy of dietary intake of vitamin D and adequacy of sunlight exposure was studied in the two groups. Mean Vitamin D levels were 23.23 ± 6.81 ng/ml in cases, 29.27 ± 8.89 ng/ml in controls (p < 0.0001). Vitamin D deficiency was found in 57% of cases and 33% controls (p < 0.0001). Mean Vitamin D levels were significantly lower in females with tuberculosis (20.84 ng/ml) as compared to males (25.03 ng/ml, p = 0.002). Mean BMI in patients of tuberculosis with Vitamin D deficiency were 19.51 ± 1.77 kg/m2 and in patients with normal Vitamin D were 21.65 ± 1.79 kg/m2 (p < 0.0001). Mean Vitamin D levels in patients with multi-drug resistant tuberculosis was lower to a mean of 15. 41 ± 4.67 ng/ml (p < 0.0001).

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