Abstract

FORMULATIONS OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE USING NATURAL AND SYNTHETIC POLYMERS

Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G1, Shardor A G*

ABSTRACT

The primary benefit of a sustained release dosage form compared to a conventional dosage form, is the uniform drug plasma concentration and therefore uniform therapeutic effect. Matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. The objective of the present study was to develop, evaluate and compare once-daily sustained release matrix tablets of furosemide using hydroxypropyl methylcellulose K4M and xanthan gum. The matrix tablet formulations were prepared by using different drug: polymer ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The prepared matrix tablets were evaluated for various parameters like hardness, thickness, weight variation, friability, percent drug content and in vitro drug release studies as per USP guidelines. Out of 10 formulations, the formulation SX1 is selected as best formulation which shows 76.23 % drug release in 12 hrs.

Keywords: Furosemide, Hydroxypropyl Methylcellulose K4M, Xanthan gum, Sustained release matrix tablets etc.