Abstract

COMPARISON OF ACUTE EFFECTS OF SUCRALOSE, ASPARTAME AND ACESULFAME POTASSIUM ON PULSE, BLOOD PRESSURE, AND BLOOD GLUCOSE LEVELS IN YOUNG HEALTHY ADULTS

Dr. Syed Asif Jahanzeb Kazmi*, Dr. Akbar Nawaz Khan, Dr. Muhammad Naqib and Dr. Tahir Ahmad Munir

ABSTRACT

Background: The use of non-nutritive sweeteners (NNSs) have become increasingly popular, so their health benefits and potential adverse effects should be evaluated. Methodology: This nonrandomized case-control comparative study was done at Mohi ud-Din Islamic Medical College on 200 healthy undergraduate medical students in October 2017 after approval from ethical committee. The participants were equally divided into groups A, B, C and D. The control group A was given 100 gm cellulose while participants of group B, C and D were given 0.36 gm (5 mg/kg) sucralose, 10.8 gm (150 mg/kg) aspartame and 3.24 gm (45 mg/kg) acesulfame potassium respectively in a glass of 180 ml water. The arterial pulse, systolic and diastolic pressures were measured at 0, 30, 60, 90 and 120 minutes. The random blood glucose levels were checked at 0 and 120 minutes in all the participants. Results: The random blood glucose levels showed a non-significant difference (p>0.05) at 0 and 120 minutes within and between all the study groups. A significant difference (p

Keywords: Non-nutritive-sweeteners, Pulse, Blood-pressure, Glucose.