STUDY OF ANTIOXIDANT, ANTIMICROBIAL AND ANTHELMINTIC PROPERTIES OF 1-NICOTINOYL-4-ARYL-3-METHYL 3a,4- DIHYDROPYRAZOLO [3,4c] PYRAZOLES AND THEIR INCLUSION COMPLEXES WITH ?-CYCLODEXTRIN
Sunakar Panda*, D. L. Singh
ABSTRACT
Three different fused pyrazoles with nicotinyl moiety namely 1-
Nicotinoyl-4- phenyl-3- methyl- 3a, 4-dihydropyrazolo [3, 4-c]
pyrazole, 1-Nicotinoyl-4-(2-chlorobenzylidene)-3-methyl-3a, 4-
Dihydropyrazolo [3,4-c] pyrazole and 1-Nicotinoyl-4- (4-
chlorobenzylidene) -3-methyl-3a,4-dihydropyrazolo[3,4-c] pyrazole
have been synthesized and characterized spectroscopically. To
enhance the solubility and minimise the side effects of the above
synthesized compounds, their inclusion complexes have been prepared
with β-cyclodextrin. The stability of inclusion complexes has been
ascertained from the study of spectral and thermodynamic properties.
Finally, the compounds and their inclusion complexes have been
screened for antioxidant, antimicrobial and anthelmintic properties. It is found that there
happens a significant increase in antioxidant, antimicrobial and anthelmintic activities after
the formation of inclusion complexes.
Keywords: Fused pyrazoles, ?-cyclodextrin, Inclusion complexes, Thermodynamic properties, Pharmacological properties.
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