Abstract

FORMULATION AND EVALUATION OF DOMPERIDONE COMPRESSED LOZENGES AND COMPARISION WITH DOMPERIDONE MARKETED CONVENTIONAL TABLET

B. Moulika Lakshmi*, Brahma K., G. Swathi, S. Sravani, P. Indira Rao and Dr. P. Shailaja*

ABSTRACT

The present investigation aims to design, prepare and evaluate the medicated lozenges of Domperidone for treatment of nausea and vomiting. Domperidone is a selective serotonin receptor (5-HT3) antagonist. The benefits of prepared lozenges showed increase in bioavailability, reduction in gastric irritation by passing of first pass metabolism and increases onset of action. The lozenges were prepared by compression technique using wet granulation method using HPMC K100 M, HPMC K15 M, HPMC K4 M, HPMC E5 polymers and other suitable excipients. The preparation process involves mixing of Domperidone with all excipients, used in the formulation in different ratios and subjected to FTIR for compatibility. All the prepared formulations were characterized for drug content, hardness, weight variation, moisture content, in vitro release studies. These compressed lozenges are compared with marketed conventional Domperidone tablet.

Keywords: Domperidone, Compression, lozenges, vomiting, marketed conventional tablet.