Abstract

DESIGN, SYNTHESIS AND EVALUATION OF SOME NOVEL THIADIAZOLE AND OXADIAZOLE DERIVATIVES FOR THEIR ANTIDIABETIC AND ANTIOXIDENT ACTIVITY

Prajakta Kothawade*, Rekha Bhalerao and Gauri Kulkarni

ABSTRACT

In the present work some novel substituted 1, 3, 4 Thiadiazole and 1, 3, 4 Oxadiazole derivatives were synthesized by using Aromatic acids and Thiosemicarbazide & Semicarbazide. The substitution of chloroacetone in presence of anhydrous potassium carbonates again addition the different aldehyde with malononitrile. The last step involves condensation of amino group with aldehyde, ethanol & sodium borohydride. All the synthesized compounds were characterized by IR, 1H-NMR and Elemental Analysis. All the compounds were evaluated for antibacterial activity by using cup-plate agar diffusion method. All compounds were evaluated for the antidiabetic activity by in vitro model of alpha Glucosidase inhibition. All compounds were evaluated for the in vitro anti-inflammatory activity and there after the active compounds for in-vivo activity. All the compounds were screened for antioxidant activity by Hydrogen peroxide radical scavenging activity method and phosphomolybdenum method.

Keywords: Oxadiazole, Thiadiazole, Antibacterial, Antidiabetic, Antioxident and Antiinflammatory.