Abstract

FORMULATION AND EVALUATION OF GASTRIC FLOATING DRUG DELIVERY SYSTEMS OF CARVEDILOL WITH NATURAL POLYMERS

Sowjanya Polanki*, Vadithe Vasu Naik, Areti Ankarao, P V Ayodhya Neelima, Rajesh Akki, Munagala Gayatri Ramya

ABSTRACT

The present investigation was concerned with the development of oral gastroretentive floating tablets of carvedilol, which after oral administration were expected to prolong the gastric residence time and improves the bioavailability of the drug as well as its half life. All the precompression parameters of formulation blends of Carvedilol floating matrix tablets were evaluated for Angle of repose, Bulk density, Tapped density, Compressibility index and Hausner’s ratio. All the values were within the limit as per U.S.P. The best floating performance and the best in vitro drug release profile were achieved by formulation F4 which contains Drug: xanthan gum: karaya gum in a ratio of 1:0.5:0.5 gave the drug release (99.64%) up to 24 h. For the optimized formulation, based on R2 values the best formulation follows zero order kinetics and Higuchi model and suggests the release occurs by diffusion mechanism, based on ” n” value it follows non fickian diffusion mechanism. Therefore matrix tablets with sufficient floating time and sustained release up to 24 hrs were successfully prepared.

Keywords: Carvedilol, Xanthan gum, Karaya gum, Non Fickian.