BIOAVAILBILITY ENHANCEMENT OF ARTESUNATE USING SOLID DISPERSION TECHNIQUES
Shaundarya Kumar *, Dr.Dinesh Chandra, Rakesh Singh, Vijay Kumar Singh, Usha Rai, Vaibhav Prakash Srivastava
ABSTRACT
In the present work, an attempt has been made to enhance solubility
and dissolution of poorly water soluble drug, Artesunate by preparing
solid dispersions using two hydrophilic polymers namely ,β-
cyclodextrin and PEG 6000.Drug carrier solid dispersions were
prepared by solvent Physical mixing method. Solid dispersions of
Artesunate with β-cyclodextrin and PEG 6000 markedly increase the
solubility and dissolution of solid dispersion compared to the free form
of Artesunate. The results were compared with marketed tablet of
Artesunate. The drug carrier interactions in the solid state were
investigated using saturated solubility studies, FTIR spectroscopy, Xray
diffraction and differential scanning calorimeter. The developed
formulation overcome and alleviates the drawbacks and limitations of Artesunate sustained
release formulations and could possibility be advantageous in terms of increased
bioavailability of Artesunate.
Keywords: Artesunate, Solid dispersion. Bioavailability enhancement, ?-cyclodextrin.
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