Abstract

EVALUATION OF ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF CAPPARIS MOONII OF ALBINO RATS

Dr. Vanita G. Kanase*, Gauresh Dhotre, Krish Jain, Shruti Shettigar, Rahul Gupta, Diptesh T. Patil and Dr. Sudha Rathod

ABSTRACT

The present study is designed to explore the mechanism of action formulation of Capparis moonii against experimentally induced gastric ulcers. The effect of Aqueous extracts of Capparis moonii was investigated in rats to evaluate the anti-ulcer activity by using three models, i.e. Aspirin, Alcohol and pyloric ligation models experimentally induced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity, ulcer score and ulcer index. Omeprazole (20mg/kg) was used as positive control. The results indicate that the aqueous extract of capparis moonii (AECM) significantly (P < 0.05) decreases the volume of gastric acid secretion, PH, free acidity, total acidity, ulcer score and ulcer index with respect to control and comparable with Omeprazole.

Keywords: Capparis Moonii, Anti-Ulcer, Pyloric Ligation, Gastric Secretion, Ulcer Index.