Abstract

FORMULATION AND STABILITY STUDIES OF AMOXYCILLIN AND POTASSIUM CLAVULANATE CHEWABLE TABLET

Monika Sharma*, Jugaldas Chudasama, Prabhu Narayan, and Pratap Singh Rathore, Ashok Kumar Sharma

ABSTRACT

Amoxycillin/Clavulanic acid or co-amoxiclave is a combination antibiotic consisting of amoxycillin trihydrate, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxycillin-resistant bacteria that produce β- lactamase. 10 formulation of the amoxycillin and potassium clavulanate chewable tablet are formed with increasing or decreasing the conc. of disintegrant and diluents. These formulations are formed, evaluated and study accelerated stability studies for the best formulation .Accelerated stability studies of amoxycillin and potassium clavulanate chewable tablet was performed as per ICH guidelines. Various parameters are analyzed including description, assay, dissolution, water content, and microbiological quality. These parameters were evaluated at 0 month, 1 month, 2 month, 3 month and 6 month intervals.

Keywords: Amoxycillin Trihydrate, Potassium Clavulanate, Accelerated stability studies, Chewable tablet, Dissolution study.