Abstract

TO STUDY THE EFFECT OF COW GHEE AND ALOE VERA ON THE PERMEATION OF ACYCLOVIR

Jagruti A. Shahare*, Ashwin R. Lanjewar, Dinesh M. Biyani, Pravin K. Bhoyar

ABSTRACT

For transdermal delivery to be effective, drugs have to enter into the viable skin in sufficient quantities to produce a therapeutic effect. The objective of present research work is to formulate acyclovir gel which shows the potential in the topical delivery of a hydrophilic drug and reduces the dosing frequency, side effects, increases the therapeutic efficacy and improves the patient compliance. Acyclovir is a potent and highly selective inhibitor of viruses of herpes group, such as herpes simplex virus type 1 (HSV1) and type 2 (HSV2), varicella zoster virus, and to a lesser extent against Epstein Barr virus and cytomegalovirus. pH of all formulas was found to be up to 6.9, practical yield above and up to 95%, spreadability was found to be 10.9, viscosities of all the formulations were found in the range of 18300 to 62830 cps and lying within the limit of 50- 50,000 cps.pH, drug content were also found to be have satisfactory results with low standards deviation values. Viscosity studied indicate that increase the viscosity with increase the conc. With cow ghee and increase the permeability of drug through skin. In-vitro drug diffusion of acyclovir from gel & Ex-vivo drug release profile of acyclovir from gel was monitored wasobserved that its increase the permeability of drug in comparision of without cow ghee formulation. The method devised to prepare gel was effective and reproducible. The result of present investigation indicated that Transdermal gel of acyclovir prepared with combination of polymer (carbopol 934P), and different permeation enhancer is possible.

Keywords: Cow ghee, Acyclovir, Aloe vera, penetration, transdermal.