SPECTROPHOTOMETRIC METHODS FORMULATIONS ESTIMATION OF NIACIN AND SIMVASTATIN IN TABLET DOSAGE FORM
Dhamdhere Rupali Balasaheb*, Varsha A. Dighe and Manjusha C. Nevase
ABSTRACT
Two simple, sensitive, rapid spectrophotometric methods have been
developed for simultaneous estimation of Niacin (NIA) and
Simvastatin (SIM) in tablets. First method involves solving
simultaneous equations based on measurement of absorbance at two
wavelengths 263 nm and 238 nm λ max of Niacin and Simvastatin,
respectively. Second method is based on absorbance ratio method
(QAnalysis). Beer’s law was obeyed in the concentration range of 2-
20μg/ml and 2-20μg/ml for Niacin and Simvastin, respectively. The
methods were validated as per ICH guidelines. Statistical analysis
proved that the methods were accurate, precise, and reproducible for
analysis of Niacin and Simvastatin in tablets. The wide linearity range, sensitivity, accuracy
and simple procedure imply that the proposed technique demonstrated to be appropriate for
routine analysis and quality control assay of tablets.
Keywords: Niacin, Simvastatin, simultaneous equation method, absorbance ratio method. (Q Analysis).
[Download Article]
[Download Certifiate]