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Abstract

IMPROVEMENT OF DISSOLUTION PROPERTIES OF EFAVIRENZ BY INCLUSION COMPLEXATION USING CYCLODEXTRIN

Bharathi A.*, Abhilash, Ch. Sri Sailaja and D. Chandra Sekhar Naik

ABSTRACT

Efavirenz (EFV) is an oral antihuman immunodeficiency virus type 1 drug with extremely poor aqueous solubility. Thus, its gastrointestinal absorption is limited by the dissolution rate of the drug. The objective of this study was to characterize the inclusion complexes of EFV with β-cyclodextrin (β-CD) and ϒ-CD to improve the solubility and dissolution of Efavirenz. The Binary inclusion complexes of Efavirenz were prepared by physical mixture, solvent evaporation method, kneading method in (1:1) ratios of two types cyclodextrins. The pre and post parameters are excellence values obtained from all the ratios it over all formulations ϒ-CD kneading method showed the heisted percentage of drug release compared other methods. It can be concluded that the inclusion complexation technique is an effective approach for the dissolution rate improvement of poorly water soluble drugs such as Efavirenz.

Keywords: Efavirenz, Inclusion complexation.


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