Abstract

REVIEW ON“DISSOLUTION RATE ENHANCEMENT TECHNIQUES”

Ashwini V. Jadhav*, Dr. Sandip S. Kshirsagar and Nikhil S.Bhujbal

ABSTRACT

The enhancement of 0ral bioavailability of poorly soluble drug remains one of the most challenging aspects of drug development. Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters. To achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, and solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.

Keywords: Bioavailability, Dissolution, Lipophilic, Poor solubility.