Abstract

TIME DEPENDENT PHARMACOKINETICS: A REVIEW

Mohd Abdul Hadi*

ABSTRACT

In order to design proper protocol for drug administration is consideration of circadian rhythm in drug pharmacokinetics. Several studies have concluded that all organisms including humans are highly organized by circadian rhythms. These changes in cycles will influence on physiological function thus, can influence on pharmacokinetics phases. Drug pharmacokinetic parameters can be changed according to the time of administration. The main objective of the chronopharmacokinetic study is to control the time of administration which among others can be responsible for variations of drug kinetics but also chronopharmacological effects observed with certain drugs. This article gives brief information regarding the changes of pharmacokinetics of the drug due to circadian rhythms.

Keywords: Chronopharmacokinetics, circadian rhythms, absorption, distribution, metabolism, elimination, chronopharmacology.