FORMULATION AND EVALUATION OF EFFECT OF DIFFERENT STABILIZER AT NANOSUSPENSION OF SATRANIDAZOLE
Vijay kumar singh*, Preeti singh, Dinesh Chandra, Usha Rai ,Saundarya kumar, Praveen singh
ABSTRACT
The solubility and dissolution properties of drugs play an important
role in the process of formulation development. Among all newly
discovered chemical entities most of the drugs are lipophilic and fail to
reach market due to their poor water solubility. Literature survey
reveals that, amoebiasis is the second leading cause of death from
parasitic disease worldwide. Satranidazole was selected as the drug of
choice because it is most potent nitroimidazole derivative and
clinically useful against common protozoa; it is twice as effective as
other nitroimidazole against amoebiasis. The aim of the present
investigation was to find out the effect of different stabilizer on the
formulation of satranidazole nanosuspension. The prepared
nanosuspensions were evaluated for Particle size, Polydispersity Index,
Zeta potential analysis, SEM, solubility, %yield, drug content, %EE, invito drug release
studies and DSC curves obtained confirms the transfer of drug crystalline form to amorphous
form. Solubility studies and in-vitro drug release studies shows that the prepared
nanosuspension has increased solubility and dissolution rate compared to pure drug.
Keywords: Satranidazole, Nanosuspension, Nanoprecipitation method,solubility enhancement.
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