Abstract

DESIGN AND SYNTHESIS OF HYBRID AZOLES AS POTENTIAL NON CAMPTOTHECIN TOPOISOMERASE INHIBITORS

John Thomas*, Mahendra Shiradkar Jisha James Golwala Dharmesh

ABSTRACT

A variety of novel Hybrid triazolyl indeno[1,2-c]isoquinolines 14-33 derivatives were synthesized in good yields and characterized by IR, 1H NMR, mass spectral and elemental analyses. All the newly synthesized compounds were evaluated for their in-vitro anticancer activity and topoisomerase I inhibition. Several compounds showed interesting cytotoxic activities when compared with the Doxorubicin as a reference drug.

Keywords: Hybrid triazoles, topoisomerase inhibitors.