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Abstract

DEVELOPMENT OF DISCRIMINATIVE DISSOLUTION MEDIA FOR MARKETED METOPROLOL SUCCINATE EXTENDED RELEASE TABLETS

Pilli Gayathri Devi*, Soumya Missula, Kondempudi Sai Krishna Mohan, Koyyani Rakesh, kolluri Ramakrishna, Y.A.Chowdary

ABSTRACT

The present study was undertaken to assess the interchangeability of the various ER metoprolol succinate dosage forms on the basis of their in vitro dissolution characteristics with three commercial SR brands, as it is a cardioselective beta blocker which has been classified as a class I substance according to the BCS [1], meaning that it is highly soluble and highly permeable at a strength of 50 mg . Medias included in dissolution procedure are 0.1 N HCl (pH 1.2), acetate buffer (pH 4.5), distilled water (pH 7.0), and phosphate buffer (pH 6.8) were evaluated, as the drug is readily and completely absorbed throughout the whole intestinal tract [2-4] but is subjected to extensive firstpass metabolism resulting in incomplete bioavailability (about 50%) depending on this intention this indiscriminative study has been taking place for the development of futher technology in formulation of Metaprolol succinate.

Keywords: Metaprolol succinate,discriminative dissolution,extended release tablets.


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