Abstract

ALLOPURINOL INDUCED TOXIC EPIDERMAL NECROLYSIS

Dr. R. Kavitha*, Dr. S. Srinath and Dr. Sunil M. Vishwasrao

ABSTRACT

Toxic epidermal necrolysis is a rare but potentially a life threatening fatal disorder most often occurs due to the adverse drug reaction. The mechanism behind this disorder is not clearly understood. There are many drugs known to cause such fatal reaction, one among is allopurinol. It is commonly used in chronic gout but known to cause many adverse reactions like toxic epidermal necrolysis and steven Johnson syndrome. We present a case of a 67 year old male, who developed generalized maculopapular lesion with painful blisters involving more than 30% of body surface area for the past 2 days after administration of allopurinol and was diagnosed as drug induced toxic epidermal necrolysis. Due to timely intervention and appropriate treatment the patient was rescued from a life threatening disorder.

Keywords: Allopurinol, chronic gout, toxic epidermal necrolysis, adverse drug reaction.