Abstract

FORMULATION & EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF PROPRANOLOL

Surendranath Betala*, M. Mohan Varma and K. Abbulu

ABSTRACT

Formulated Propranalol sustained release microspheres. Microspheres are prepared by Ionic-Gelation method using Hydroxy Propyl Methyl Cellulose (HPMC), Ethyl cellulose and Sodium CMC for sustained release in view to prolong drug release. Propranalol is an adreno receptor beta blocking agent used in the treatment of hypertension and characterized by high solubility and low permeability which corresponds to BCS class III drug. Plasma half life ranges from 4 to 7 hrs & oral bioavailability is 40-50% hence require frequent oral administration for adequate treatment of hypertension. Administration of conventional tablet of Propranalol has been reported to exhibit fluctuations in plasma drug levels resulting in either manifestation side effects reduction in drug concentration at receptor site. So that oral sustained dosage form was developed. The microspheres were evaluated for various characteristics like encapsulation efficiency, percentage yield, partial size and the In vitro release for 12 hrs. The Microspheres were found to be discrete, spherical, and free-flowing. The microspheres were uniform in size, and the microencapsulation efficiency was in the range of 52.5-81.7%. Microspheres had good spherical geometry.

Keywords: Microspheres, Hypertension, In vitro release, Encapsulation efficiency.