Abstract

EFFECT OF LINEZOLID ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS

Bheemreddy Thrinitha* and Keerthana Arra

ABSTRACT

A drug interaction is a change in the effect of a drug when taken with a certain other drug, a supplement or food. Its effect may increase or decrease or a side effect may occur. When a therapeutic combination could lead to an unexpected change in the condition of the patient this would be described as an interaction of potential clinical significance. The study is to Estimation of blood glucose levels by GOD-POD method. To determine whether Linezolid have any influence on the pharmacokinetics and pharmacodynamics of pioglitazone in normal rats. To determine whether Linezolid have any influence on the pharmacokinetics and pharmacodynamics in diabetic rats. To find out the pharmacokinetics parameters of pioglitazone and its interaction mechanism this helps to avoid adverse effects without compromising therapeutic benefit. Experiments were performed with wistar rats procured from Mahaveera Enterprises (Hyderabad, A.P., India), weighing between 180 to 210gms. The animals were housed in colony cages (four per cage) under conditions of standard lighting, temperature (22±1oc) and humidity for at least one week before the beginning of experiment, to adjust to the new environment and to overcome stress possibly incurred during transit. The present study results suggest that, initial treatment (single dose studies in nomal rats) Linezolid enhanced the bioavailability of Pioglitazone. In multiple dose studies also Linezolid increased the bioavailability of Pioglitazone and these results were found to be statistically significant. So, the combination of Linezolid and Pioglitazone should be contraindicated or should be used with caution in a clinical situation. Well-designed controlled studies in human beings are needed to confirm the interaction.

Keywords: Linezolid, Bioavailability, Pioglitazone, contraindicated.