Abstract

IMMUNOMODULATORY SCREENING OF PLUMERIA ACUMINATA STEM BARK

K. Sunitha* and G. Krishna Mohan

ABSTRACT

In the present work, it was studied that methanolic extracts of Plumeria acuminata possess immunomodulatory activity. The dried stem bark was extracted with methanol for active constituents. Then that extracts were administered to the experimental animals using standard methods viz. the haemagglutinating antibody titre was used to assess humoral immune response and Carbon clearance test have shown to be exhibit significant immunomodulatory activity. We evaluated delayed type hypersensitivity by the difference between the pre and post challenge footpad thickness. The data were analyzed and obtained values at a dose of 300mg/kg body weight when compared to that of the standard drug, showed the extract to be immunomodulant drug.

Keywords: Plumeria acuminata, Immunomodulatory activity, Carbon clearance test, Delayed type hypersensitivity, Haemagglutinating titre.