Abstract

FORMULATION AND IN VITRO EVALUATION OF NIFEDIPINE EFFERVESCENT FLOATING MATRIX TABLETS BY USING HYDROPHILIC POLYMERS

Asfia Kauser*, Taiyaba Fatima, Ayesha Haseena and Zaara Majeed

ABSTRACT

In the present research work gastro retentive floating matrix formulation of Nifedipine by using various hydrophilic polymers were developed. Then the formulation was developed by using different concentrations of polymers of Gum cyamposis, xanthan gum and sodium alginate as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations gum cyamposis as polymer were retarded the drug release up to desired time period i.e., 12 hours in the concentration of 60 mg. whereas in low concentrations the polymer was unable to produce the desired action. (F3 Formulation, 99.36% Drug release). The formulations prepared with sodium alginate were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order mechanism of drug release.

Keywords: Nifedipine, Hydrophilic polymers, Floating tablets.