Abstract

SYNTHESIS OF 1, 3, 4-OXADIZAOLE INCORPORATED THIOFIBRATES FROM SUBSTITUTED BENZOIC ACIDS

Niranjan M. S.* and Chaluvaraju K. C.

ABSTRACT

The present discussion describes about five derivatives 5a to 5e of 1, 3, 4-oxadizaole incorporated thiofibrates. These were synthesized from the starting material substituted benzoic acids 1a to 1e. Methyl esters 2a to 2e of these acids are converted into their hydrazides 3a to 3e by refluxing with hydrazine hydrate. Further reaction with carbon disulphide in 10% potassium hydroxide gives corresponding thiophenols incorporated with 1, 3, 4-oxadizole 4a to 4e. Ethyl-2- bromoisobutyrate in dimethylformamide converts these into their thiofibrates 5a to 5e in presence of anhydrous potassium carbonate. Physical data such as m. p, TLC and spectral data IR, NMR, Mass confirms their assigned structures.

Keywords: 1, 3, 4-oxadizole, thio fibrates, Ethyl-2-bromoisobutyrate, synthesis, hypolipidemia.