Abstract

CLINICAL STUDY OF OSTEOCALCIN AND ITS RELATION TO DIABETES MELLITUS

Thikra A. Allwsh and Liqa'a S. Abdulla*

ABSTRACT

The research included estimate the concentration of osteocalcin in control and diabetic patients (Type I and Type II). The results demonstrated that the normal mean of osteocalcin in serum was (28.07 ± 4.79 ng/mL) in control group for both sexes, their ages range between (less or equal than 15-more or equal than 65) year. also, the results demonstrated a significant decrease in the concentration of osteocalcin in serum of type I and type II diabetic patients compared with control and between type I diabetic patients compared with type II and it was affected by age and sex, in control and diabetic patients, also showed a significant decrease according to BMI in control and diabetic patients (Type I and II), aswellas showed significant decrease of osteocalcin in serum of fasting and smoking of type I and type II diabetic patients compared with control, while found a significant increase according to menopausal of females and year’s seasonals in control and diabetic patients (Type I and II), whereas showed a significant graduated decrease in the concentration of osteocalcin when glucose concentration increase in diabetic patients, while found a significant increase in the concentration of osteocalcin in the patients who treating with insulin, whereas showed a significant decrease in the concentration of osteocalcin when the disease's period increase in diabetic patients as well as the patients affected by other diseases compared with diabetes mellitus only.

Keywords: Osteocalcin, Diabetes, Insulin, Year’s seasonals, Disease's period.