Abstract

NASAL INSERTS DRUG DELIVERY SYSTEM: A REVIEW

S.K.Patil*, A.B.Darekar, R.B.Saudagar

ABSTRACT

Nasal drug delivery system is a useful delivery system for the drugs that are in low doses. Nasal drug delivery system provides easy application of drug with self administration. Nasal inserts are novel, bioadhesive, solid dosage forms for prolonged systemic drug delivery via nasalroute. Nasal inserts are prepared by lyophilization. The process of lyophilization involves a container closed with an impermeable membrane pierced with one or more holes through which the material in the container can be lyophilized. The advantages of nasal inserts are-Pain free and self administered, Convenient and easy to use, safe. The nasal inserts can be evaluated by-water uptake study, invitro drug release study, bioadhesive potential of inserts, differencial scanning calorimetry. drug content determination, surface pH. Nasal inserts are small device and light in weight. Disadvantages of nasal inserts are.-all drugs cannot be given by nasal route, Frequent use of this routes leads to nasal mucosal damage, Drug cannot be withdrawal if once administered.

Keywords: Nasal inserts, lyophilisation, surface pH, sustainable, mucosal damage, nasal route.