Abstract

FORMULATION AND EVALUATION OF DISPERSIBLE TABLET OF AMOXICILLIN TRIHYDRATE

Mamatha G. T.*, Pradeepa N., Priyanka Raj G., Vinay Kumar G. V. and Tamizh Mani T.

ABSTRACT

In present study, the oral dispersible tablets of Amoxicillin Trihydrate were prepared by direct compression technique using microcrystalline cellulose (MCC) as direct compressible diluents. Sodium starch glycolate (SSG), Croscarmellulose sodium (CCS) and Crospovidone used as synthetic superdisintegrants. The amoxicillin dispersible tablet powder blends showed satisfactory flow properties. Seven formulations were prepared using different concentrations of superdisintegrants and were investigated for their effect on the disintegration time and dissolution rate of the tablets. Tablets were also evaluated for weight variation, hardness, thickness, friability and % drug content. All the tablets exhibited acceptable pharmacotechnical properties. Tablets prepared with the blend of CCS (15mg) and crospovidone(15mg) exhibited quicker disintegration. According to the present study, it was found that tablets of batch F4 (blend containing CCS & crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40 min.).

Keywords: Dispersible tablet, dispersibility, dissolution, Amoxicillin Trihydrate.