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Abstract

PREPARATION, CHARACTERISTIC EVALUATION AND DISSOLUTION ENHANCEMENT OF AMLODIPINE BESYLATE BY POLYMORPHISM TECHNIQUE

Subramanian L.*, Ramanathan M., Shanmugaraja V., Sornalatha A., Vandhana P. and Vijayalakshmi M.

ABSTRACT

Amlodipine besylate is well known and commonly recommended anti-hypertensive medicine, it act by blocking the calcium channels. In general onset of action and bioavailability is most essential concern for drugs using in cardiac treatments. Amlodipine besylate is pharmacologically well effective, but it has lesser solubility character which influences slow the rate of dissolution which affect bioavailability. The present study describes preparation of Polymorphic crystal, characteristic evaluation and dissolution enhancement of Amlodipine besylate by Poly morphism technique. The crystals prepared by using solvent kneading method with various aqueous and non-aqueous solvents (Distilled water, Ethyl acetate, Carbon tetra chloride and Benzene). The prepared polymorphic Amlodipine besylate crystals was evaluated in various parameters of Percentage yield, Compound microscopic, Scanning Electron Microscopic character, Melting point, FT-IR, and dissolution study. The prepared Amlodipine besylate polymorphic crystal using Ethyl acetate solvent produce best dissolution rate.

Keywords: Amlodipine, Bioavailability, FT-IR, Polymorphism, Scanning Electron Microscopic character and Melting point.


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