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Dr. Venkata Ramudu, M. Jeevana Sravanthi*, G. Ramyasree and Dr. P. Gowtham Kumar Reddy


Although many newer anti psychotic medications have been developed over the past several decades, one of the first generation anti psychotic drug, haloperidol is still widely used in the treatment of schizophrenia and major depressive disorders. It decreases the negative thoughts and effectively reduces or eliminates psychotic symptoms in many patients. It is often found to reduce the aggression; however extra pyramidal symptoms are concerns associated with its use. Here we present a case of extra pyramidal symptoms (muscular rigidity and motor abnormality) induced by Haloperidol of dose 10 mg in a 30yrs old female patient with the diagnosis of Severe depression with psychotic symptoms. She is previously a known depressive psychotic patient, under anti psychotic therapy since one month. At present to manage her aggressiveness, prescribed with Inj. Haloperidol 10 mg along with Inj. Phenargon 25 mg, but on evaluation we found that only haloperidol was administered. So, this may be the reason for developing severe muscular rigidity and motor retardation and the suspected ADR was probable ADR (Naranjo’s scale). Inj. Phenargon 50 mg is used to treat the condition. Hence it is often essential that clinicians regularly evaluate patients for these conditions to prevent their emergence and progression.

Keywords: Haloperidol, Schizophrenia, ADR (adverse drug reaction), Extra pyramidal symptoms, Depressive psychosis.

[Full Text Article]

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