Abstract

PROTECTIVE EFFECT OF ZINC SULFATE, SILYMARIN IN THALLIUM INDUCED MODEL OF NEPHROTOXICITY

Faruk K H. Al-Jawad, Khalifa E. Sharque, Saad B. Nashtar and Hasan A. Al-jezani*

ABSTRACT

Objective: Nephrotoxicity (NT) is a serious state with multi factorial cause. The present study was designed to determine the protective effect of zinc sulfate & Silymarin when they are given orally before or after (NT) induced by the toxic agent thallium. Material & Methods: The renal function tests of S.urea-nitrogen & S. creatinin & S. electrolytes K, Cl and Na of both agents were determined in 72 healthy albino rats before or after (NT) induced by Thallium whenas treatment last for five successive days. Results: showed significant decrease in creatinin levels of both Zinc sulfate & Silymarin in pre and post treatment forms measured at 120 hr compared with control group. The histopathological examination showed an obvious improvement in the sections of renal tissue that support the renal effect of these agents on nephrotoxicity in Thallium poisoning. Conclusion: Both agents possess protective effect against (NT) caused by thallium. In general, post treatment forms are slightly more effective than pre treatment forms of these agents & all can be used as anti dote in thallium poisoning.

Keywords: Zinc sulfate, Silymarin, nephrotoxicity, Thallium poisoning, Renal protection.