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  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF MOXONIDINE TRANSDERMAL PATCH WITH HYDROPHILIC POLYMER

*Abhinay Chhetri, Biplab Kumar Dey and Nihar Ranjan Bhuyan

ABSTRACT

The aim of the present study was to formulate Anti-Hypertensive drug (Moxonidine) transdermal patch by Die-cast method using different concentration of hydrophobic polymer with and without enhancer. The preformulatory aspects which included FT-IR studies also revealed the facts that the polymers used were safe and no untoward disturbances in the vibration of the functional groups of the molecules were observed. It can be concluded that the used polymers namely Sodium alginate, Hydroxy propyl methyl cellulose as Hydrophilic along with the drug Moxonidine were safe for further formulatory works. The prepared transdermal patch of Moxonidine containing 4% Polyvinyl alcohol as the backing membrane with the rational blend of polymers along with the required quantity of drugs were found to be elegant free from any abnormal deformities. The drug diffusion profiles also revealed the fact that the polymer matrix was functioning properly with zero order kinetics as desired. The release sequence of hydrophobic polymer can be summarised formulation FC>FE>FF>FG as without enhancer and FC*>FE*>FF*>FG* with enhancer. Selected formulation (SA:HPMC), formulation FC* (1:3) [with enhancer] showed the maximum release of 86.16 % and formulation FC (1:3) [without enhancer] showed the maximum release of 55.92 % were found to be the best formulation.

Keywords: Drug Moxonidine, hydrophilic polymer, Sodium alginate, Hydroxy propyl methyl cellulose, transdermal patch.


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