Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF PYRUS PASHIA LEAVES IN RATS

Neha Pandey, Anita Singh* and Janmejay Pant

ABSTRACT

The objective was to investigate the antidepressant activity of methanolic extract of Pyrus pashia leaves (MEPPL) in albino rats. In this study rats were separated into 4 groups (n=6/group), 1st group was denoted as control group in which only distilled water was used, 2nd group was denoted as standard group in which Imipramine hydrochloride (15mg/kg) was used as standard and rest 2 groups were denoted as test groups (T1, T2). Two doses of the methanolic extract of Pyrus pashia leaves (MEPPL) (100 and 200 mg/kg) were used as T1 and T2 respectively. Control, standard and test samples (Imipramine and dried extract of Pyrus pashia leaves) were administered via gavage through oral route (p.o). The outcomes demonstrated that a dose dependent antidepressant activity in FST and LMA. The fundamental discoveries of the MEPPL altogether reduced the immobility times in the FST (p<0.001) similarly, the concentrate additionally altogether expanded the locomotion, rearing and defecation effects in comparison to the control group (p<0.001). The present outcomes obviously show that the MEPPL has antidepressant activity in FST and LMA. The current study could be of therapeutic interest for using in the treatment of patients with depression.

Keywords: Pyrus pashia, Antidepressant Activity, Forced Swim Test, Locomotors Activity.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More