Abstract

EVALUATION OF VEDICPYRIN A POLYHERBAL PREPARATION FOR ITS ANTIPYRETIC, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY

Harisha R.*, Bharathi K. N. and Chandrasekar S. B.

ABSTRACT

Objective: To evaluate antipyretic, analgesic and anti-inflammatory activity of polyherbal formulation, vedicpyrin. Materials and methods: Polyherbal formulation was used at 180, 360 mg/kg and 260, 520 mg/kg in rat and mouse respectively. Antipyretic activity evaluated by brewer’s yeast induced hyperthermia in rats; analgesic activity evaluated by acetic acid induced writhing test and hot plate method in mice. Anti-inflammatory activity studied in rats by carrageenan induced paw oedema and cotton wool granuloma models and biochemical estimation was carried out for lysosomal enzymes (ALT, AST) and total protein in the same models. Results: The polyherbal formulation shown significant antipyretic activity but less than paracetamol, analgesic activity was found significant in both models and anti-inflammatory activity shown was significant in paw oedema model as well as cotton wool granuloma method. Elevated level of lysosomal enzymes and total protein significantly reduced in anti-inflammatory models. Conclusion: The polyherbal formulation shown prominent antipyretic, analgesic and anti-inflammatory activity.

Keywords: Carrageenan, brewer’s yeast, writhing, hot plate, lysosomal enzymes.