Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

SYNTHESIS, SAR STUDIES AND EVALUATION OF NOVEL BENZOTHIAZEPINES AS ANTIMICROBIAL AGENTS

Dr. Bushra Ahmed Kateb*, Abdulkareem Ali Hussien and Santosh M. More

ABSTRACT

Microbiology, Yeshwant Mahavidyalaya, Nanded-431602. ABSTRACT One of the most widely employed methods for the preparation of 1,5- benzothiazepines involve the reaction of 2-aminothiophenol with 1, 3- dicarbonyl compounds. A series of 1,5-benzothiazepines have been Synthesized by the reacting of 2-aminothiophenol benzaladehyde and 2,4-pentane-dione, Aluminum Nitrate(10 mol%) in 20 ml ethyl alcohol. The synthesized benzothiazepines were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger,. DMSO was used as a solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of 1,5-benzothiazepines derivatives have been a topic of special interest to organic and medicinal chemists.

Keywords: 2-aminothiophenol, 2,4-pentane-dione, SARstudies, Antibacterial activity.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More