Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE OSMOTIC TABLET OF GLIPIZIDE

Dr. Khaja Pasha* and Dr. Shahana Banu

ABSTRACT

Controlled porosity osmotic pump tablets of Glipizide were prepared and final formula is optimized after formulating four formulations by using different polymers, two factors, osmogent ratio and coating percentage are varied and evaluated based on their effects on drug release rate. Tablets of all formulations are prepared by Direct compression method. As the osmogent concentration and pore former increases, drug release increases in the present work, four fomulations are prepared and F3 formulation is optimized.

Keywords: Osmotic drug delivery, osmosis, coating, zero order release.