Abstract

FORMULATION EVALUATION AND OPTIMIZATION OF METFROMIN HCL MATRIX TABLET USING NATURAL POLYMER

Ruhul Amin, Trideep Saikia and Dr. Biswajit Das*

ABSTRACT

Objective: The overall objective of the present work was to develop an oral sustained release metformin HCL tablet using hydrophilic hydroxyl propyl methylcellulose and Xanthan gum polymer as rate controlling factor. Method: The excipients used in this study did not alter physicochemical properties of the drug, as tested by Fourier transform Infrared Spectroscopy and the thermal analysis using differential scanning calorimetry. Tablets were prepared by direct compression method using 10 mm punch. All the formulation was evaluated for thickness, weight variation, hardness, and drug content uniformity. Drug release kinetic models are evaluated to study the best release pattern. Result: Drug content was found to be 99%-101%. Hydrophilic matrix of HPMC alone could not control the Metformin release effectively for 12 h whereas when combined with Xanthan gum could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets. The F8 formulation shows the drug release up to 97% Fitting the data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release and having R2 values above 0.9. Conclusion: Thus, a stable, safe natural release retardant i.e.; xanthan gum, which can be effectively used in tablet formulation for sustain release of the drug.

Keywords: HPMC, Xanthan gum, Matrix tablets, Release kinetics.