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Abstract

SPECTROPHOTMETRIC DETERMINATION OF SOME FLOUROQUINOLONE DRUGS IN TABLETS

Gehad G. Mohamed, Shaban M. Khalil, Samah H. Mahmoud

ABSTRACT

This work described the use of spectrophotometric methods for the determination of some antibiotic flouroquinolone drugs namely sparfloxacin (SFX), levofloxacin (LFX), ofloxacin (OFX) and enrofloxacin (EFX) in pure form and in tablets. The first method is based on charge transfer complex formation between these drugs as nelectron donors and 7,7,8,8-tetracyanoquinodimethane (TCNQ) and 5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptors. The experimental conditions for these CT reactions have been carefully optimized. Beer’s law is valid over the concentration range from 5-150 and 5-180 μg mL-1 of SFX, LFX and OFX and SFX, LFX and EFX drugs using DDQ and TCNQ reagents, respectively. The second method is based on ion-pair formation between these drugs and Mo(V)-thiocyanate reagent in sulphuric acid medium and extraction with 1,2-dichloro-ethane. Beer’s law is valid over the concentration range from 10-150, 10-125, 10-90 and 10-90 μg mL-1 for SFX, LFX, OFX and EFX drugs, respectively. Different analytical parameters namely molar absorptivity (), standard deviation, relative standard deviation, correlation coefficient, limit of detection and quantification are calculated. The results obtained by the proposed methods are in good agreement with those obtained by the official method as indicated by the percent recovery values. The methods are applied for the determination of these flouroquinolone drugs in tablets.

Keywords: Floroquinolone drugs; DDQ; TCNQ; Mo(V)-thiocyanate; spectrophotometry; charge-transfer; ion-pair formation.


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