A REVIEW ON APPROACHES TO ORAL CONTROLLED DRUG DELIVERY SYSTEM VIA GASTRORETENTION
Londhe Kirti A*, Gondkar Sheetal B, SaudagarRavindra B
ABSTRACT
Oral route of drug administration is the most preferable route because
of its flexibility in formulation, ease of administration, and patient
compliance. But this route has certain limitations like limited gastric
residence time (GRT) for sustained drug delivery system and for the
drugs which are absorb from specific region of gastrointestinal tract
(GIT). To overcome these limitations, various approaches have been
proposed to increase the gastric retention time of the delivery system in
the upper part of gastrointestinal tract. Gastroretentive dosage form
(GRDF) prolongs the GRT by targeting site-specific drug release in
upper part of GIT. GRDFs enable continuous and the extended
duration of drug release and improve bioavailability of drugs that have
narrow therapeutic window, by this way they prolong dosing interval
and increase compliance of the patient. The purpose of this article is to
compile the various gastroretentive approaches. In order to understand various physiological
difficulties to achieve gastric retention, we have summarized important factors controlling
gastric retention. Finally the evaluation parameters of gastroretentive drug delivery systems
are covered.
Keywords: Oral controlled release, Gastric retention, Absorption window.
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