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Abstract

DESIGN AND EVALUATION OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF ANTI-HYPERTENSIVE DRUG LOSARTAN POTASSIUM

Motugatla. Prasad*, E. Bhavya, Vedachalam. Gunasekharan

ABSTRACT

The main objective of the present work is to develop a Novel osmotically controlled drug delivery system of Losartan Potassium. It was aimed to prepare for prolonged residence in the stomach over conventional Gastro-retentive approaches. Losartan Potassium tablets were prepared by direct compression method employing different polymers like HPMC K4M, HPMC K15M, Carbopol 974P in different proportions along with sodium bicarbonate as a gas generating agent. FTIR and DSC studies showed that drug and polymers are compatible. The prepared granules were evaluated for angle of repose, compressibility index and hausner’s ratio and results obtained were satisfactory compressed formulations were further evaluated for weight variation, hardness, thickness, friability, buoyancy studies, drug content and in-vitro dissolution studies. All the formulations showed good results which were compliance with pharmacopoeial standards. Among all formulations HPMC K15M grade provided better controlled release characteristics with excellent drug release and buoyancy. Among all formulations it was concluded that the formulations with K15M is optimized for better release, and FM 8 formulation is optimized among the K15M formulations because of its equal combination of osmotically controlled polymer and hydrophilic polymer.

Keywords: Osmotically controlled drug delivery, Losartan potassium, HPMC K15M, Direct compression, Buoyancy studies.


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