Abstract

FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF STAVUDINE

Prof. Mahesh S. Gadge*, Krishnakumar K. Saurkar and Prajakta N. Dongare

ABSTRACT

The sustained release matrix tablet of Stavudine was prepared by direct compression method using hydrophilic HPMC K4M, carbopol 934P and hydrophobic Eudragit RSPO polymers. The release of Stavudine from matrix tablet can be controlled by changing type of polymer or by its concentration. As the concentration of hydrophilic polymers increased the drug release rate from matrix tablet were decreased. By increasing concentration of Eudragit RSPO in formulation, the drug release rate also increased. In vitro release data fitted into Hixson-Crowell kinetic model suggest that the highest correlation coefficient was showed by F5 and F6 formulation batches, but present cumulative drug release for F5 was found to be 95.64% and percent cumulative drug release for F6 was found to be 92.67% as the percent cumulative drug release of F5 was higher than F6. Hence, F5 selected as an optimized batch. Optimized batch F5 were stable at the selected temperature and humidity in storage for 28 days. The best fit model was Hixson-Crowell model followed by Korsmeyer peppas, Higuchi model and first order. The value of correlation coefficient was found to be 0.998 for F5 formulation. finally it concluded that the prepared sustained release matrix tablet of Stavudine may prove to be potential candidate for safe and effective drug livery over an extended period of time.

Keywords: Stavudine, Eudragit RSPO, Sustained release, Matrix tablets, Hixson-Crowell model.