Abstract

SYNTHESIS & ANTIMICROBIAL STUDIES ON NOVEL PYRIMIDINES DERIVED FROM PIPERAZINE CHALCONES

J. Ranjith Kumar*, S. Ushasri, T. Swetha, B. Sunil Reddy and MD. Yasmeen Begam

ABSTRACT

Treatment of 3-substituted phenyl-1-(4-(4- hydroxyl phenyl)- piperzin-1-yl)-Prop-2-en-1-ones with guanidine hydrochloride in presence of ethanol and potassium hydroxide, formed 4- substituted phenyl-6-(4-(4- hydroxyl phenyl)- piperzin-1-yl)- Pyrimidinyl derivatives (RP-1 to RP-10). These are assayed for their antibacterial activity against Bacillus pumilus, Bacillus subtilis, Escherichia coli and Proteus vulgaris; for antifungal activity against Aspergillus niger and Candida albicans strains. Antibacterial assay revealed that, compounds RP-2, 3, 7, 8, 10 were highly effective against Bacillus subtilis and Proteus vulgaris and in the antifungal assay, compounds RP-3, 10 proved to be effective against Aspergillus niger.

Keywords: 4- substituted phenyl-6-(4-(4- hydroxyl phenyl)- piperzin-1-yl)- Pyrimidinyl derivatives, antibacterial activity, assay, effective, antifungal activity.