Abstract

MECHANISM OF FLAVONOIDS ACTION IN SMOOTH MUSCLE RELAXATION

Shahnawaz Ahmad Wani, Haris Iqbal and Seemi Farhat Basir*

ABSTRACT

Hyper contraction of Smooth Muscle is related to various diseases like hypertension, asthma, coronary resistance. Most of the contractile pathways are related to endothelial dysfunction and rise in extracellular calcium. To counter the hyper contractile response of smooth muscles flavonoids act as relaxant molecules or inhibitors of contraction. In this paper we have reviewed the mechanism of action of some known flavonoids such as quercetin, Galetin 3-6-dimethyle ether, kaempferol, fisetin, catechin, apaginin wogonin, naringeinin, formonontin, genistein, daidzen, ayanin, pulicarin. These compounds show endothelium dependent relaxation and play role in enhancing nitric oxide (NO) and endothelium independent relaxation by blocking calcium channels and potassium channels. We have not limited our literature survey to organ bath related research papers but we have included both invivo and invitro studies in this review so that this review may help researcher to make correlation between both studies.

Keywords: Smooth muscle relaxation and contraction, Calcium Channels; Cyclic Nucleotide; Quercetin; Relaxant Effects; Rutin; Galetin 3,6-dimethyl ether; phosphodiesterase; ERK1/2, Fisetin, MYPT1, Phorbol ester, Rho-kinase; L-NAME (N?-Nitro-L-arginine methyl ester)