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Abstract

SYNERGISTIC ACTIVITY OF BARK EXTRACTS OF PONGAMIA GLABRA AND FICUS GLOMERATA IN ALLOXAN-INDUCED DIABETIC RATS

Sanjeev Heroor*, Arunkumar Beknal1, Nitin Mahurkar

ABSTRACT

Polyherbal therapy is said to be a better choice in the treatment of diabetes mellitus having the advantage of producing maximum therapeutic efficacy with minimal side effects. In the present study the combination of low doses of methanolic extracts of Pongamia glabra (PBME) and Ficus glomerata (FBME) was subjected for determination of its antihyperglycemic effects in comparison with their individual treatments and a standard hypoglycemic agent, glibenclamide. The effect of combination of extracts was evaluated in normal and alloxaninduced diabetic rats using the parameters such as glucose tolerance test, acute and sub-acute levels of antidiabetic study and body weight estimations at various intervals. Glibenclamide was administered orally at 600 μg/kg. PBME and FBME were individually administered at 100 (low dose) and 200 mg/kg (high dose) respectively. Combination of 100 mg/kg (low doses) of PBME and FBME was also administered. Significant (P<0.01) hypoglycemic effect was noticed with the combination therapy of low doses of PBME and FBME compared to their individual treatments at both doses and glibenclamide in the parameters studied and it was also able to produce more percentage increase in body weight than the individual treatments. It is concluded from the study that the combination therapy of low doses of PBME and FBME showed synergistic antihyperglycemic effect. This could provide an opportunity to reduce the dose of antidiabetic herbal drugs to achieve an enhanced therapeutic effect with minimal side effects.

Keywords: Polyherbal therapy, Pongamia glabra, Ficus glomerata, glibenclamide, hypoglycemic effect.


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