Abstract

EFFECT OF GENISTEIN PHENYLPIPERAZINE DERIVATIVE ON TRAUMATIC ORAL ULCER

Chuanxing Feng, Qi Wang, Hui Li and Quancheng Zhou*

ABSTRACT

The present study was performed to probe into the effect of genistein phenylpiperazine derivative (GPD) on traumatic oral ulcer so as to provide theoretical guidance and practical data for such areas as food and drug. A traumatic oral ulcer model in guinea pig was built by phenol (90%) burn method and the indicators of guinea pig were determined in this study to investigate the pharmacological mechanism of GPD’s effect on traumatic oral ulcer. The findings showed that high-dose GPD brings about remarkable therapeutic effect on traumatic oral ulcer (P<0.01). Furthermore, concentrations of SOD (47%), AMPK (84%), IL-10 (132%) and PEG-2 (12%) increase significantly (P<0.01) while the concentrations of MDA (40%), mTOR (62%), ROS (36%), NO (20%), NF-κB (8%) and TNF-α (33%) in guinea pig plasma (P<0.01) obviously decreased as compared with the vehicle. GPD has a significant effect on treatment of traumatic oral ulcer by inhibiting inflammatory reaction, improving oxidative stress, and suppressing the growth and reproduction of inflammatory cells.

Keywords: Genistein, Derivative, Piperazine, Traumatic oral ulcer, Guinea pig.