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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUTION OF SUBSTITUTED 2-PHENYL BENZIMIDAZOLE DERIVATIVES

Kamma.Madhavi*, N. Raghavendra Rao, N. Srinivasa rao, B.Raju.

ABSTRACT

Benzimidazole is important pharmacophore and privileged structure in medicinal field with so many pharmacological activities. Literature survey shows that among the Benzimidazole derivatives, 2-phenyl Benzimidazoles are found more potent. The substituted Benzimidazole derivatives possess different pharmacological activities antiinflammatory, anti-microbial, antifungal, and antiulcer activities etc. And hence the design and synthesis of 2-substituted Benzimidazoles are potential area of research. So synthesised to N-Mannich base of substituted 2-phenyl Benzimidazole derivatives was synthesised by using O-Phenylene diamine with different aromatic acids with corresponded to N-mannich base. Finally the synthesised compounds were characterized by TLC, MP & Spectral data. Synthesised compounds screened to antibacterial & antifungal activities by cup plate method and also evaluated for anti-inflammatory activity determined by carrageenan induced method.

Keywords: Substituted 2-phenyl Benzimidazoles, Carrageenan induced method, antiinflammatory activity, cup plate method, antibacterial activity, antifungal activity.


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