Abstract

DESIGN AND DEVELOPMENT OF METFORMIN HYDROCHLORIDE BILAYERED SUSTAINED RELEASE TABLTES

T.V.Rao*, N.Bhadramma, R.Naga swetha and U. Naga Raju

ABSTRACT

Diabetes is one of the major causes of death and disability in the world. Diabetes results from decreased secretion of insulin, decreased insulin action or both. The main aim of the investigation was to design and development of bilayer floating tablets of metformin hydrochloride and also study the influence of concentrations of HPMCK 100 on various properties of tablet. Bilayer tablets were formulated by wet granulation method. Drug - excipient compatibility studies were conducted by FTIR spectroscopy. The prepared granules and tablets were evaluated. In-vitro release data revealed that F5 formulation sustained the release for 12 hrs, the release data was fitted into zero order, first order, Higuchi and Peppas equations .The drug release from the formulation followed zero kinetics and exhibits Peppas mechanism. Release exponents ‘n’ was found less than 0.85 indicating the release governed by nonfickian anomalous transport mechanism.

Keywords: Bilayer floating tablets, Hydroxy propyl methyl cellulose.