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Abstract

DEVELOPMENT AND CHARACTERIZATION OF GREEN TEA LOADED GEL FOR THE TREATMENT OF ACNE

Pratibha Nand*, Sushma Drabu, Rajinder K. Gupta

ABSTRACT

Green tea is found to be rich in polyphenols having antibacterial, antioxidant properties. The aim of the present study was to investigate the potential of gel formulation for topical delivery of green tea in the treatment of acne. The leaves were subjected to sequential extraction using Soxhlet apparatus. High performance thin layer chromatography quantified catechin (0.458 %w/w) and High Resolution Gas Chromatography Mass Spectroscopy identified terpinen-4-ol (1.39%), main components responsible for anti-acne activity. The antimicrobial activity of extracts and GTME (methanolic extract of green tea) loaded gel was measured by disc diffusion methods against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes indicating antimicrobial potential of GTME loaded gel in the treatment of acne.

Keywords: Green tea extract; antibacterial; anti-oxidant; GC-MS; HPTLC.


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