Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: JUNE ISSUE PUBLISHED
  • JUNE 2021 Issue has been successfully launched on 1 June 2021.

Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME PYRAZOLE DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITY

M. SajaniRaju*, E. Venkatanagaraju, Amit Kumar Das, K. Sumesh,C. Swetha and
D. Agilandeshwari

ABSTRACT

This work has been undertaken for the synthesis and pharmacological evaluation of some pyrazole derivatives for anti-inflammatory activity. 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one obtained from phenyl hydrazine and ethyl acetoacetate was acetylated and then subjected to Claisen-Schmidt condensation with 4-hydroxy benzaldehyde to get a chalcone. This chalconewas cyclized with the help of hydroxylamine hydrochloride to form an isoxazole derivatives which were further condensed with various substituted aromatic aldehydes to obtain titled compounds (4aD1-4aD15). The structures of new synthesized compounds were confirmed by IR, 1H NMR and Mass spectral data. Synthesized derivatives were evaluated for their anti-inflammatory activity. The compound 4aD3, 4aD8, 4aD9, 4aD10 and 4aD14was found to have comparable anti-inflammatory activity with that of standard drug indomethacin.

Keywords: Pyrazoles,synthesis,anti-inflammatory,indomethacin.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More