Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME PYRAZOLE DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITY

M. SajaniRaju*, E. Venkatanagaraju, Amit Kumar Das, K. Sumesh,C. Swetha and
D. Agilandeshwari

ABSTRACT

This work has been undertaken for the synthesis and pharmacological evaluation of some pyrazole derivatives for anti-inflammatory activity. 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one obtained from phenyl hydrazine and ethyl acetoacetate was acetylated and then subjected to Claisen-Schmidt condensation with 4-hydroxy benzaldehyde to get a chalcone. This chalconewas cyclized with the help of hydroxylamine hydrochloride to form an isoxazole derivatives which were further condensed with various substituted aromatic aldehydes to obtain titled compounds (4aD1-4aD15). The structures of new synthesized compounds were confirmed by IR, 1H NMR and Mass spectral data. Synthesized derivatives were evaluated for their anti-inflammatory activity. The compound 4aD3, 4aD8, 4aD9, 4aD10 and 4aD14was found to have comparable anti-inflammatory activity with that of standard drug indomethacin.

Keywords: Pyrazoles,synthesis,anti-inflammatory,indomethacin.