Abstract

FIXED DOSE COMBINATION OF RANITIDINE AND DICYCLOMINE

Kamlesh Valuba Bhuse (M. Pharm)*

ABSTRACT

Ranitidine exhibit competitive inhibition at the parietal cell H2 receptor and suppress basal and meal-stimulated acid secretion in a linear, dose-dependent manner. It is highly selective and dose not affect H1 /H3 receptor. The volume of gastric secretion and the concentration of pepsin are also reduced. Ranitidine reduces acid secretion stimulated by histamine as well as gastrin and cholinomimetic agents through two mechanism. 1) Histamine released from ECL cells by gastrin or vagal stimulation is blocked from binding to the parietal cell H2 receptor. 2) Direct stimulation of the parietal cell by gastrin or acetylcholine results in diminished acid secretion in the presence of H2 receptor blockade. Dicyclomine is an ant muscarinic, anticholinergic agent. It is nonspecific, local, direct spasmolytic action on the smooth muscle of GIT. This combination is effective in both ulcer and smooth muscle spasm.

Keywords: Ranitidine, Dicyclomine.